Background and Aim: The lack of effective interventions for amphetamine addiction remains a significant public health concern worldwide. The purpose of this study was to determine the effectiveness of the Matrix therapy programme in developing emotional self-regulation and reducing the risk of relapse among a sample of amphetamine addicts at the Mental Health Hospital in Taif. Participants: The study sample included twenty-two males diagnosed with amphetamine abuse disorder, with an average age of 37.77±7.65 years, and visitors to the Mental Health Hospital in Taif. Methodology: Emotional Self-Regulation and Relapse Risk were used as study scales. The Relapse Risk Scale was translated into Arabic and used to determine the effectiveness of the 16-week Matrix therapy programme. Cronbach's alpha, Spearman and Brown half-fractionation methods were used to test the scale's stability and reliability. Mann-Whitney and Wilcoxon Rank test was applied to the data using SPSS. The treatment programme lasted 16 weeks. Findings: The results revealed that the Matrix therapy programme significantly (p=0.05) developed emotional self-regulation of positive cognitive strategies (acceptance, positive refocus, focus on plans) and reduced negative strategies (self-blame, rumination, blaming others). However, the programme did not affect dimensions such as re-evaluation of positive re-appraisal, setting the record straight, putting into perspective, and catastrophic thinking. The effect size (r) for the therapeutic programme in the experimental group compared to the control group on the dimensions of emotional self-regulation of statistical significance ranged from 0.697 to 0.854, indicating a large effect. The treatment programme effectively lowered (p=0.05) the risk of relapse among amphetamine addicts with a large effect size (r=0.848) between the experimental group and the control group.