The political role of global major powers in resolving the Muslim-Jewish geographical conflict in Palestine in the 21st century remains a complex and contentious issue. Key players, including the United States, Russia, and the European Union, have often sought to mediate peace through diplomacy, negotiations, and economic aid. However, geopolitical interests, historical alliances, and varying approaches to Middle Eastern stability have influenced their involvement. While some powers advocate for a two-state solution, others align with one side, exacerbating tensions. This abstract explores how global powers’ strategies, interventions, and competing national interests continue to shape the trajectory of peace efforts in the region. Moreover this paper explores how these global players’ competing interests, strategies, and diplomatic engagements shape the conflict’s resolution prospects, highlighting the challenges in achieving a lasting peace between Muslims and Jews in Palestine.