Genetically modified crops are making a significant improvement to agriculture regarding crop quality and quantity under rapidly shifting environmental conditions, helping to meet the societal demands of foods. Genetically modified crops are employed to determine their suitability in different localities of the country to increase crop yield. This study aimed to evaluate three genetically modified wheat varieties: Faisalabad-2008, Punjab-2011, and Shafaq-2003 in the local environment of Dera Ghazi Khan, Punjab Pakistan. Each modified variety of wheat was planted in four (04) rows/plot. The plot was 6×23 m with 25 cm row spacing. Yield parameters including no. of tillers, germination count^-2, plant-height, no. of spikelets/spike, no. of grains per spike, spike length, 1000-grains weight, and production of grains were determined after the application of fertilizers. Nitrogen (N), potassium (K), and phosphorus (P) sources were usedas fertilizers i.e. urea for N, triple super phosphate for P, and potash sulphate and K. Statistical analysis was performed to evaluate the significant difference in crop phenological parameters including no. of tillers, germination count^-2, plant-height, number of spikelets/spike, no. of grains/spike, spike length, 1000-grains weight, and grains production. Faisalabad-2008 showed significantly highest production due to higher yield parameters followed by Punjab-2011 and Shafaq-2003.