The purpose of this study is to evaluate the impact of four key factors i.e. venue, match conditions, toss outcomes, toss decisions on ground-specific highest run chases in Twenty20 international cricket (T-20I) using a full factorial design.  The study uses a stepwise regression model to analyze match data from Pakistan, Australia, India, and New Zealand in order to find significant influences on average scores pursued. The findings show that toss decision (TD) and its interactions with venue (Vn) and match condition (MC) are important predictors of run chase outcomes; the final model accounts for 66.8% of the variation in scores. To improve the predicted accuracy of the model, future study ought to consider about incorporating more variables like team makeup, individual player performance, and weather etc.