Background: Endoscopic mucosal resection (EMR) is a significant advancement in treating early cancers of the upper and lower gastrointestinal tract.

Objective: To evaluate the Effectiveness, complication, and recurrence of flat colonic polyps following endoscopic mucosal resection (EMR).

Methods: A prospective trial was conducted in Lady Reading and Khyber Teaching Hospitals of Peshawar, Pakistan from Jan 2021 to Jan 2023.

Results: A total of 243 polyps were resected in 211 patients. 23 patients had more than one polyp. The mean age was 45±13 years. En-bloc resection was possible in 240 patients (98.8%). Bleeding immediately after resection was seen among 6 patients (2.84%) while delayed bleeding after 24 hours after the procedure occurred in 8 patients (3.8%). Perforation occurred in one patient. The recurrence rate was 9 % (18/205) during a follow-up of 12 months.

Conclusion: Endoscopic Mucosal Resection is an effective and safe outpatient procedure for sessile or flat colonic polyps.