In recent decades, technological entrepreneurship has become a critical topic. It plays a crucial role in growth & economic modernization. The technology-based industries expansion at traditional industries expense underscores need to identify factors contributing to Pakistan technological entrepreneurship's success. Larkana is also known for solid economic condition and generously funded by Sindh province. Larkana City has dynamic population of around 364,033 (as of 2019) and covers an area of 7,423 square kilometres. The study also aims to explore technological entrepreneurship on poverty, using Larkana City as a case study. The empirical findings reveal that technology entrepreneurship initiatives essential in alleviating poverty. Our results also indicate technological entrepreneurship offers abundant opportunities in various sectors including agriculture, construction, craftsmanship, information technology, manufacturing, mining, finance, insurance, wholesale and retail trade, providing employment opportunities. The study provides baseline information & learns experiences from fast-growing districts and replicates strategies in other districts, which boosts entrepreneurship process that might enhance per capita income and increase poverty reduction initiatives.=