A study was conducted at Institute of Social Sciences, Gomal University, Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan during 2023 to make economic analysis of Wheat crop cultivation in district Dera Ismail Khan (commonly known as D.I.Khan). Three tehsils namely D.I.Khan, Parova and Paharpur were selected on the basis of purposive sampling technique. From each tehsil, three villages were selected and five wheat varieties Khaista and Wadan, Pirsabak-15, Pirsabak-19, and AZRC-Dera were grown. Primary data were collected from 900 respondents (farmers) randomly selected through structured questionnaire. Sample size was allocated to these nine villages on the basis of proportional allocation method. For data analysis, benefit cost ratios, log-linear Cobb-Douglas production function and marginal rate of substitutions were estimated. According to the results benefit cost ratio was noted for Khaista-2017, Wadan-2017, Pirsabak-2019, AZRC Dera-2020 and Pirsabak-2021 were 1.89, 1.99, 1.96, 2.19 and 2.14 respectively, thus the AZRC Dera-20 variety is the most profitable variety of wheat as compared to all other wheat varieties. The output elasticities of area, tractor hours, fertilizer, seed, labour and pesticides were observed as 0.3112, 0.0012, 0.5924, 0.6212, 0.5124 and 0.0013, respectively. The input-output relationship holds increasing returns to scale. The farmers should be advised to cultivate high yielding varieties like AZRC Dera-20 and Pirsabak-21.