Mental health issues are alarmingly prevalent in Pakistan and there is a need for attention to cultural nuances of mental disorders like depression and anxiety. This study explored the conceptualization, perception understanding, causes, solutions and consequences of youth, and medical and mental health practitioners regarding depression and anxiety in local Pakistani context. Data was collected through four focus group discussions (N=26). Results were grouped into five major themes: (1) conceptualization, (2) signs and symptoms, (3) risk factors (4) protective factors, and (5) awareness. The complex role of cultural, religious, environmental, social, educational, occupational, and familial factors was unveiled