China's economic ascent in the 21st century has put the US's global leadership in perils. However, like with any major geopolitical game, certain nations are more important to US interests than others, with India being the most important. The Sino-Indian enmity and competition for regional hegemony have been a serious concern for the policy makers round the globe. In the current Sino-US rivalry, the United States' interests converged with those of India’s. Both countries have engaged in a Strategic Partnership specially in the current century to counterweight China. This study gives a qualitative overview of China’s contentious relations with both the US and India and the US-India partnership to contain Chinese expanding tentacles in the global politics. Focusing on the qualitative research design, this study discusses the Indo-US strategic partnership and the possibility of all the challenges that might be faced towards forging a trust worthy relations between the two states. By rigorous contextual and document analysis, the current study recommends that the lasting peace and stability lies in the balance of power among the regional player and regional connectivity that may enhance trust and prosperity among the nation states.