Bank employees facing a critical situation of occupational stress, highest working hour and job burnout that leads to severe medical pathos including hyperlipidemia, hypertension, diabetes, and further more absurd life style including smoking and liquor, hot shots. The objective of this study is to estimate the prevalence of psychological problems associated with risk factors of heart disease among bank employees in Pakistan and also explore the mediating role of psychological capital in relationship between occupation stress and job burnout among bankers having or without cardiac disease. The results indicated that Psychological Capital occupational stress and job burnout are strongly correlated among each other and also the bankers associated with cardiac disease psychological capital partially mediate the relationship between occupational stress (extrinsic effort, reward and over commitment) and emotional exhaustion similarly psychological capital fully mediate the relationship between over commitment and depersonalization. Furthermore, psychological capital partially mediates the relationship between reward and personal accomplish while fully mediate the relationship between over commitment and personal accomplish.