This study looks into the relationship between employee cynicism and deviant workplace behaviour, with a focus on self-esteem as a mediator and employee resilience as a moderator in Pakistani Higher Education Institutions (HEIs). Data was gathered from employees at various HEIs in Pakistan, and structural equation modelling was used to examine the relationships between the variables. The findings show a significant positive relationship between employee cynicism and deviant workplace behaviour. Furthermore, self-esteem was partially mediate this relationship, implying that low self-esteem is associated with higher levels of deviant behaviour. Furthermore, employee resilience was found to moderate the relationship between employee cynicism and deviant workplace behaviour, implying that higher levels of resilience may reduce the negative effects of cynicism on workplace behaviour. These findings shed light on the complex dynamics that exist within HEIs and offer valuable insights for fostering a positive work environment and improving organisational effectiveness.