Raising a child with autism poses distinct challenges for parents. Maternal acceptance of the diagnosis and associated behaviors promotes positive family adaptation. This study aimed to examine emotional regulation and cognitive flexibility as intrapsychic predictors of maternal acceptance among Saudi mothers of autistic children. A sample of 50 mothers completed self-report measures of emotional regulation, cognitive flexibility, and acceptance. Correlation analysis found significant positive associations between emotional regulation, cognitive flexibility, and acceptance. Regression analysis indicated both emotional regulation and cognitive flexibility as significant positive predictors of maternal acceptance, with emotional regulation evidencing a stronger relationship. These results empirically validate theorized links between coping capacities and acceptance that have previously been established primarily through qualitative research. Findings also extend the predominantly Western literature by demonstrating relevance within a novel Saudi cultural context. This research provides guidance for designing psychosocial interventions to assist families managing autism globally. Targeting parental emotional regulation and flexible thinking may improve acceptance and adaptation across cultures.