Introduction: Giant intracranial cerebropontine angle (CPA) lesion is hard to access, bleeding and other complications are common. Thiopental sodium, often used for anesthesia induction, can help in quickly and smoothly inducing anesthesia. We aimed to describe a case to show the efficacy and safety of total intravenous anaesthesia and thiopental sodium for the management of giant CPA mass.Case description: A 55-year-old male presented with headaches, hearing impairment, and occasional loss of consciousness, without chronic diseases. He showed stable vital signs and a Glasgow Coma Scale score of E4M6V5. Radiological assessment revealed a mass compressing the brainstem. During surgery, careful positioning and anesthesia were conducted, with minimal bleeding and relaxed intracranial vessels noted. Cerebrospinal fluid drainage and appropriate treatment were administered. In the ICU, he received ventilator support and medication. After successful tumor excision, he regained consciousness within a day and was closely monitored in the inpatient ward for four days, with a follow-up consultation scheduled after one week.Conclusions: In this case, effective management of a sizable cerebropontine angle meningioma in a 55-year-old male patient was demonstrated through the strategic utilization of thiopental sodium.