This research aims to 1) study the growth, yield, quality, and production efficiency of lettuce cultivated in different hydroponic systems, 2) Develop a control system for the growth of lettuce in diverse hydroponic setups, utilizing Internet of Things (IoT) technology for all elements, and 3) compare the effectiveness of traditional lettuce production methods with automated control systems using IoT technology. The research equipment included 1) an automated control system, 2) applications, and 3) hydroponic cultivation methods. Statistical analysis includes mean, standard deviation, and t-test. The findings of the research reveal that 1) the growth, yield, quality, and production efficiency of lettuce in various hydroponic systems differ significantly and are generally very good, 2) the development of a growth control system for lettuce in different hydroponic setups, integrated with IoT technology, results in a comprehensive and efficient system with excellent performance across all functions, 3) the comparison between traditional lettuce production methods and automated systems with IoT technology shows significant differences. Lettuce grown in hydroponic systems controlled by IoT exhibits higher concentrations of all phytochemicals and better antioxidant capabilities than traditionally cultivated lettuce.