The Role of PPAR-γ agonist to Improved Wound Healing in Diabetes Mellitus
Doctoral Program, University of Padjadjaran, West Java, Indonesia
Arief S Kartasasmita
Ophthalmology Department, University of Sriwijaya, South Sumatera, Indonesia
Shanti F Boesoirie, Wijana
Ophthalmology Department, University of Padjadjaran, West Java, Indonesia
Ramzi Amin
Otorhinolaryngology, Head and Neck Surgery Department, University of Padjadjaran, West Java, Indonesia
Abstract
Aim To provide evidence regarding the role of PPAR-γ agonist to improved wound healing in diabetes mellitus.Methods PubMed, Science Direct, ProQuest, Cochrane and Wiley Online Library were searched for any design study that explore the role of PPAR-γ to improved wound healing in diabetes mellitus. Four studies were identified and analysed from 16 initial ar ticles Data were then extracted from the studies and summarized descriptively Results Sixteen articles were screened, and four studies were identified and eventually selected. All four selected studies were conducted in USA, China and Germany. There were 55 diabetic mice in these studies. Fifty dibetic mice with excisional wound (seven mice with obesity) and fourty diabetic mice with burn wound Conclusion PPAR-γ agonists and highly glucose-stimulated macrophages can accelerate wound healing by tending to enhance granulation tissue formation, angiogenesis and collagen deposition; suppress inflammatory signals from mature adipocytes; and induce VEGF mRNA and protein expression from cultured keratinocytes