Genetic risk assessment is a cornerstone, evaluating an individual's genetic makeup through factors such as genetic variants, family history, and environmental influences to discern predispositions to specific diseases. However, there are several challenges and areas for improvement that need consideration. For instance, future research in preventive genomics will need to address how to best implement effective interventions at scale, consider cost implications, and determine the factors that characterize successful interventions. Additionally, there is a need to address the anticipated workforce shortage in certain medical specialties, such as rheumatology, by expanding training, increasing the utilization of telemedicine, and reducing burnout among practicing professionals. Moreover, the successful and sustainable implementation of preventive interventions, particularly in older adults, requires further insight into their attitudes towards prevention and reasons for participating in prevention trials. This insight can inform the design and recruitment of future interventions and public health policy. Methods encompass genetic testing, family history analysis, and lifestyle factor assessment. Implementing preventive genomic medicine in a LMIC presents a complex interplay of challenges and opportunities shaped by resource limitations and contextual nuances. The challenges include constrained financial and infrastructure resources, creating hurdles for genomic technology investment. The sustainability of current strategic frameworks relies on the capacity of public health programs, requiring leadership support and sufficient time to attain genomic workforce competency. Weaknesses in current preventive strategies, such as incomplete facilities and insufficient promotion, need addressing for sustainability.