Exploring the Ellagic Acid Potential Mechanism Againts Inflammation and Bone Development Using Network Analysis
Department of Prosthodontics, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin, South kalimantan, Indonesia
Intan Nirwana
Department of Dental Materials, Faculty of Dentistry, Airlangga University, Surabaya, East Java, Indonesia
Michael Josep Kridanto
Department of Prosthodontics, Faculty of Dentistry, Airlangga University, Surabaya, East Java, Indonesia
Juliyatin Putri Utami
Department of Biomedicine, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin, South kalimantan, Indonesia
Bayu Indra Sukmana
Department of biology oral, Faculty of dentistry, Lambung Mangkurat University, Banjarmasin, South kalimantan, Indonesia
Abstract
Ellagic acid (EA) is very beneficial for human health, especially for its therapeutic potential in inflammation and osteoblastogenesis. This study aimed to determine the mechanism of EA intervention on target proteins SMAD3 and AKT1. The EA bioactive compound (PubChem ID 5281855) was downloaded as canonical SMILES. Protein targets and interactions were predicted using the Similarity Ensemble Approach target prediction web server, Swiss Target Prediction, STRING webserver, and Cytoscape version 3.9.0. As a result, EA target proteins play roles in inflammation, osteoblast development and differentiation, and bone. EA is predicted to interact with SMAD3, and this interaction with SMAD3 is thought to help the role of EA in tooth repair. Moreover, betweenness centrality results from Cytoscape, Akt is a node that has a major role in tissue pathways. In conclusion, EA can help in tooth repair, which is predicted to possess anti-inflammatory and support bone development via SMAD3 and AKT1.