Chronic liver damage leads to the development of cirrhosis, a multisystem illness when damaged tissue gradually replaces healthy tissue. Cirrhosis's effects are not limited to the loss of hepatocytes but it also suffers from ongoing systemic and local inflammation, which exacerbates liver damage it increases the chance of organ loss, increases sensitivity to infection, and prolongs liver damage. This research was carried out in the governorate of Al-Diwaniyah.  Samples were taken at Al-Diwaniyah Teaching Hospital between August 9^th, 2023 and January 8^th, 2024. It included 50 male participants (Abuser of alcoholic beverages). 25 of the subjects had just been diagnosed with cirrhosis, whereas the other 25 had been suffering from it for at least 5 years, the condition was diagnosed by measuring enzyme levels GOT, GPT, total protein and albumin. The research also included measuring the levels of some inflammatory indicators in patients with cirrhosis who were newly infected with the disease and others who had been suffering from it for at least 5 years. These indicators included measuring the level of CRP, TNF-α, IL-1β. The results showed that there is a statistically significant difference in CRP concentration between Group A and Group B below the 5% significance level, with a t-test value of 11.499 and a significant value sig. Equal to zero, which is less than the 5% significance level. We also observe a statistically significant difference in TNF concentration between Group A and Group B that is less than the 5% significance limit, with a t-test value of -41.842 and a significant value sig. Equal to zero, which is less than the 5% significance level. The t-test value of -1.941 with a significant value of 0.058 indicates a statistically significant difference between Group A and Group B in terms of IL-1β concentration, falling below the 10% significance level. Our research found a correlation between serums TNF-α and IL-1β levels and disease development and prognosis. The study compared TNF-α and IL-1β concentrations in two groups of cirrhosis patients. It was observed that the IL-1β and TNF-α were lower in group A than in group B. Based on the high quantities in group B, we may deduce that they are connected with the growth and development of liver cirrhosis. The goal of this study is to analyze the link between the levels of inflammatory proteins and the severity of the illness in persons with liver cirrhosis and following its progression.