Kurdish Studies

ISSN: 2051-4883 | e-ISSN: 2051-4891
Email: editor@kurdishstudies.net

In Vitro Antibacterial, Anti-Biofilm Activities and Synergistic Effect of Amlodipine Against Healthcare-associated Infections (Hais)

Tahane Bashir M. Ahmed
Department of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj-11942, Saudi Arabia & Microbiology Department, Faculty of Medicine - Red Sea University-Sudan
Muhammad Musthafa Poyil
Keywords: Antibacterial, Antibiofilm, Healthcare-Associated Infections Synergism, Amlodipine..


The emergences of multi-drug resistant bacterial pathogens are rising worldwide which creates serious threat to human health. The scientists across the globe have recognised the seriousness of this issue and the world health organisation has warned about the consequences that will be faced. So, the search for alternate antibacterial agents with novel modes of action has been going on all over the globe. Repurposing an old drug for other application gained much attention as the drug would already be known for its physiological activities. Hence, in the study amlodipine, a hypertension drug investigated for its antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli. The amlodipine showed potent antibacterial activity and the minimum inhibitory concentration was calculated as 150 µg/ml for E. faecalis and E. coli and for S. aureus. The amlodipine has the ability to inhibit the biofilm formation and also effectively inhibited the mature biofilms after treatment. The synergistic activity of amlodipine with two existing antibiotics revealed the synergistic effect. Overall, the amlodipine had antibacterial, antibiofilm and synergistic activity proved that it could be a promising antibacterial agent against health care associated infections.

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