The COVID-19 pandemic has introduced a host of additional difficulties for medical sciences students, impacting their mental well-being alongside the already rigorous academic demands of their programs. The study aimed to assess the prevalence of anxiety experienced by students studying medical sciences during the pandemic, along with the factors contributing to this anxiety. A survey study was conducted over three months involving students from Ras Al Khaimah Medical and Health Science Colleges. Participants were provided with an anonymous, web-based, self-administered questionnaire to collect relevant information. The prevalence of anxiety among students was 23.9%, with a mean score of 9.59±4.7 out of 21. A significant association between anxiety levels and factors such as sleep duration, a history of COVID-19 among close contacts, time management, being informed about the COVID-19 pandemic, and online learning. Logistic regression analysis identified three significant determinants of anxiety during the pandemic: inadequate sleeping hours, challenges in time management, and a history of COVID-19 among close contacts. Addressing these determinants can be instrumental in developing targeted interventions and support systems to mitigate anxiety and enhance the overall well-being of the academic community.