This research aims to illustrate the importance of developing a startup 4.0-based MSME learning curriculum in the context of the rapidly developing Indonesian economy, as well as to present the main findings from the implementation of this curriculum and its implications. In the era of industry 4.0 which is driven by technology, Indonesian MSMEs need to adopt the startup 4.0 concept to increase competitiveness. This learning curriculum is designed to provide the necessary knowledge, skills and support to MSMEs to be able to adopt and integrate technology and innovation in their business. This research includes analyzing the needs of MSMEs, developing a startup 4.0-based curriculum, implementing the curriculum, and evaluating its effectiveness. Data was collected through surveys, interviews, and document analysis. Key findings include increased understanding of startup 4.0 concepts, development of technology skills, innovative thinking, and better digital marketing. In addition, MSMEs experience increased competitiveness, income and customer relationships. The development of a startup 4.0 based MSME learning curriculum has great significance in facing challenges and opportunities in the digital era. This empowers MSMEs, contributes to economic growth, and drives sustainable innovation.