Objectives: The study aims to examine the psychometric properties of the translated Brief COPE Questionnaire in the Vietnamese context. Methods: The Vietnamese version of the Brief COPE Questionnaire underwent two steps of translation, cross-cultural adaptation, and psychometric validation as part of this cross-sectional descriptive study. University nursing students were on the front lines of the Covid-19 pandemic in the provinces and cities where outbreaks were occurring. From October to December 2021, information was gathered using the Vietnamese version of the Brief COPE Questionnaire. Results: The 23 items - brief COPE questionnaire Vietnamese version were divided into five categories of problem-focused coping, emotional-focused coping, support coping, substance abuse coping and religious coping. The loading coefficient of the observed variables were more than 0.5, therefore, the model achieved a good fit. The questionnaire's Cronbach's Alpha reliability coefficient, along with the five group variables, both exceeded 0.6. Conclusion: The five-factor, 23-item brief COPE questionnaire was indicated to have good psychometric properties in this study. This is a legitimate and trustworthy measurement for evaluating coping mechanisms among Vietnamese nursing students.