Objective: This research analyzes the front pages of newspapers in 6 countries to study how and how many times the vaccine was reported. Methods: The study focuses on 12 reference newspapers from 6 countries (two per country) and collects around 9,576 informative pieces of information corresponding to the first half of November 2020. The newspapers analyzed are The Times and The Guardian (United Kingdom), Le Monde and Le Figaro (France), La Nación and Clarín (Argentina), El País and El Mundo (Spain), The New York Times and The Washington Post (United States) and Folha de Sao Paulo and Estado (Brazil). Results: results show a predominance of news journalistic genres, while the visual frames that arise from the photographic choice tend to generate a climate of uncertainty. Supranational entities and pharmaceutical companies are the entitires that appear to a greater extent. Conclusions: this paper shows how the post-COVID-19 media scenario has repositioned the informative monitoring of health issues and has made new actors visible, focusing on medical staff, researchers and scientists.