Objective: The current research examined the relationship between perceived stigma Quality of life in people with epilepsy. It also investigated the role of moderation On the relationship of perceived stigma with quality of life.Methods: Using a survey design, a Convenience sample N = 100 (40% men, 60% women) patients diagnosed with epilepsy who attended Follow-up clinic in the Neurology Unit, outpatient clinics at Menoufia University for those aged 18 to 50 years Data for this study were collected using the Stigma Scale for Epilepsy (SSE) and a measure of The Quality of Life in Epilepsy Inventory (QOLIE-31). Data was They were analyzed using Pearson's multiple correction IBM/SPSS Version 25.0Results: Recognizing results as having significant interaction Between perceived stigma there is life and the results revealed a direct and telling relationship between them Perceived stigma and frequency of epileptic seizures. It was also shown that theconclusion: the perception of stigma and Quality of life can lead to important deliberations among perceivers Stigma exists among people with epilepsy.