This study investigates the growing influence of Middle Eastern non-state actors as agents of foreign policy and their interactions with states through an analysis of the U.S.-Kurdish relationship. Incorporating archival data and interviews with Kurdish and American policy makers, the paper analyses the factors that have affected the U.S.-Kurdish relationship from World War II to the recent Syrian crisis in the context of the mainstream theoretical approaches within the discipline of International Relations. The article concludes that the failure to formulate a coherent Kurdish policy complicates the U.S.’ Middle East strategy and contributes to outcomes unfavourable to U.S. interests in the region.