COVID-19 and Subclinical Hypothyroidism as Dual Modulators of Myocardial Infarction Risk: A Clinical-Biochemical Perspective

Authors

  • Muhammad Imran Aftab
  • Tahir Maqbool

DOI:

https://doi.org/10.53555/ks.v12i3.3981

Abstract

Background: Subclinical hypothyroidism (SCH) is a risk factor for cardiovascular disease (CVD), particularly myocardial infarction (MI), due to its association with dyslipidemia, inflammation, oxidative stress, and endothelial dysfunction. COVID-19 exacerbates these risks by disrupting thyroid function and the renin-angiotensin system (RAS).

Methodology: This retrospective study included 90 MI patients (45 with and 45 without COVID-19). Thyroid function, lipid profiles, oxidative stress, and inflammatory markers were assessed. Cardiac severity was evaluated using ECG changes, levels of biochemicak markers like troponin I, CK-MB.

Results: SCH patients had elevated TSH (6.2 vs. 4.8 mIU/L, p < 0.05), LDL (157.2 mg/dL), triglycerides (189.6 mg/dL), oxidative stress (MDA: 5.2 nmol/mL), and CRP (12.6 mg/L, p < 0.01). Cardiac injury markers and hospital stays were significantly worse in COVID-19 MI patients.

Conclusion: SCH is an independent risk factor for MI, worsened by COVID-19. Routine thyroid screening in MI patients and further research on thyroid hormone therapy (THRT) are recommended.

 

Author Biographies

Muhammad Imran Aftab

PhD Researcher, IMBB, University of Lahore, Lahore, Pakistan.

Tahir Maqbool

Assistant Professor of Physiology, IMBB, University of Lahore, Pakistan.

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Published

2024-05-30

How to Cite

Muhammad Imran Aftab, & Tahir Maqbool. (2024). COVID-19 and Subclinical Hypothyroidism as Dual Modulators of Myocardial Infarction Risk: A Clinical-Biochemical Perspective. Kurdish Studies, 12(3), 618–622. https://doi.org/10.53555/ks.v12i3.3981