Impact Of Environmental Factors And Lipid Imbalances On Hormonal Levels And Male Fertility In Older Individuals

Abstract

Background: A healthy lipid profile,normal Melatonin and prolactin levels is associated with healthy testosterone levels and male fertility. However, research on the exact relationship between lipid profiles, testosterone, Melatonin ,Prolactin and male fertility is ongoing, with some studies showing correlations while others do not. 

Aims and objective: A cross sectional study was carried out in groups of people living in Hunza valley and plain land of Lahore, Punjab to find out the effect of climate/environment on the lipid profile ,Melatonin, prolactin and male fertility.

Material and Methods: Study included 50 subjects from Gilgit and 50 subjects from Lahore. Age of both groups was above 65 year. Both groups of subjects apparently had no disease. Study duration was eight months. The questionnaire encompassed demographic details (such as gender, and age), location information, medical history and was filled by each group of people. Blood sample of both groups were drawn to estimate the level of total / free testosterone(testosterone Elisa kit ADI. 900-065 by ENZO) and lipid profile,Melatonin and prolactin by technique of ELISA. Levels of lipids were estimated by standard kits of Radox bearing code LE2670

Results: Majority of the Hunza group used naswar(Quid) as compared to people of Punjab smoked cigarettes. Fertility rate appears to be high in Hunza group who were using mediterranean diet compared to Punjab group. Level of testosterone is non-signifciantly higher in Hunza group as compared to their counterparts in Punjab group. Lipid profile was however significantly higher in Punjab group as compared to men above 65 years in Hunza group.

Conclusion: As compared to people living in land area (Lahore, Punjab), high level of testosterone,Melatonin whereas with low levels of lipid profile and prolactin was observed in group of people living in hilly areas. Multi-centric researches are required to further explore the relationship of fertility with lipid profile, testosterone level and climate /environment in detail to reach better conclusion.