Protective Effect of Ginseng against the Gentamicin-Induced Renal Toxicity

Abstract

A frequent adverse effect of medicines is nephrotoxicity. One of the most popular alternative therapies is ginseng, and each of its components improves renal function. Due of gentamicin's harmful effects, particularly on the kidneys, use is now restricted. The aim of the current research was to assess how ginseng affected gentamicin-induced nephrotoxicity. Twenty-one male albino rats aged 6 to 8 weeks had been divided into three groups. Group-A acted as the control group and received a typical rat diet. Gentamicin, dissolved in one milliliter of distilled water, was administered intraperitoneally to Group-B for fifteen days at a dose of 80 mg-Kg-day. For 15 days, Group-C received 100 mg-Kg[1]day of ginseng orally dissolved in 1 ml water in addition to 80 mg/Kg per day of gentamicin. Each animal had blood taken from them by heart puncture at the conclusion of the experiment in order to examine their kidney function. Then, kidneys from each animal were killed and collected for standard histopathological investigations. When compared to group A, group B's animals and kidneys were lighter, and mean serum urea, creatinine, and the intraluminal diameter of the proximal convoluted tubules all increased significantly. In this group, there were mild to severe necrotic and degenerative alterations in the proximal convoluted tubules. When ginseng and gentamicin were administered simultaneously, improvements in renal function tests, tubular diameter, and the mean body and kidney weights were all statistically significant. Ginseng seems to have some protective effects against nephrotoxicity brought on by gentamicin.